Risk of Colorectal Neoplasia in individuals with Self-Reported Family History: A Prospective Colonos
- Yu Tian
- Jan 31, 2018
- 1 min read
The increased risk of colorectal cancer (CRC) in family members of CRC patients has been well established. A meta-analysis (Butterworth AS et al, 2006) including 59 individual studies found that the risk of developing CRC was 2.24-fold and 3.97-fold higher in those people with one and ≥2 first-degree relatives (FDRs) affected, respectively, than general population. But the familial risk of advanced colorectal neoplasia (ACN) and colorectal adenoma remains unknown, even whether there is familial risk difference resulted from relationship of FDRs has still not yet been known.
A prospective study involving 16 Asia-Pacific countries/regions was conducted between year 2008 and 2015, aiming to answer above questions. The researchers recruited asymptomatic participants aged 40-70 years for CRC screening by colonoscopy, and collected socio-demographic, lifestyle, clinical information and self-reported CRC family history.
The researchers found that those people with at least one CRC-affected FDR were significantly more likely to have CRC (adjusted odds ratio (AOR)=2.02-7.89), ACN (AOR=1.55-2.06), and colorectal adenoma (AOR=1.31-1.92) than those without family history. The risk of CRC (AOR=0.90, 95% CI: 0.34–2.35), ACN (AOR=1.07, 95% CI: 0.75-1.52), and colorectal adenoma (AOR=0.96, 95% CI: 0.78-1.19) in subjects with either parent affected was similar to that of subjects with their siblings affected. These results indicate that there is high risk of CRC, ACN, and colorectal adenoma in those with family history of CRC, and there is no need to delineate the exact identity of the CRC-affected FDR due to the similarity in risk by relationship.
Comments