Circulating miRNAs with prognostic value in metastatic breast cancer and for early detection of meta
- Bao-Wen Yuan
- Feb 14, 2018
- 1 min read
Metastasis causes the highest morbidity and mortality among breast cancer (BC) patients. Identification of biomarkers that can be routinely monitored to predict onset of metastasis in BC patients and prognosis of metastatic breast cancer (MBC) patients would increase their median survival. Circulating miRNAs are the miRNA population in cell-free portion of blood and body fluids, with features of high stability, access by minimally invasive methods and possibility of repeated sampling make them ideal candidates
In this study, plasma miRNAs of 40 MBC patients were profiled by TaqMan low density arrays and miRNAs with prognostic capacity were identified. The candidates were validated initially in the 237 MBC patients of discovery cohort and subsequently in 335 BC patients of an independent validation cohort.
In summary, this study had identified individual and panels of circulating miRNAs which were validated to predict PFS and OS in plasma of BC patients, and specifically MBC patients. Additionally, they also identified circulating miRNAs with ability to detect metastasis up to 2 years prior diagnosis. In conclusion, the circulating miRNAs described here have wide application as prognostic markers and early detection markers of metastasis for BC.
Comentários